Pretreatment plasma d-dimer levels as an independent prognostic factor for overall survival among patients with advanced non-small-cell lung cancer

摘要

Objective To evaluate the prognostic accuracy of d -dimer levels for advanced non-small-cell lung cancer (NSCLC). Methods This retrospective cohort study included 651 patients initially diagnosed with advanced NSCLC. Patients with d -dimer levels ≥0.5?mg/L were included in the high d -dimer group, whereas patients with lower levels were included in the normal group. Cumulative survival was estimated using Kaplan–Meier curves and compared using the log-rank test. Multivariate analyses were performed using the Cox proportional hazards model. Results The median plasma d -dimer level in the study cohort was 0.61?±?0.49?mg/L. d -dimer levels were elevated in 60.98% of patients, and 80.1% of such patients had adenocarcinoma. Univariate and multivariate analyses identified d -dimer content as an independent factor for the prognosis of NSCLC (hazard ratio [HR]?=?1.54, 95% confidence interval [CI]?=?1.19–1.98). Kaplan–Meier analysis revealed that high plasma d -dimer levels were associated with shorter overall survival (HR?=?1.48, 95% CI?=?1.19–1.84). In addition, the receipt of &2 lines of treatment was associated with a higher risk of death than the receipt of &2 lines. Conclusion The present results imply that pretreatment plasma d -dimer levels could represent a prognostic factor for advanced NSCLC.