Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service

摘要

Study objectives: Determine whether dissection a?￥12 lymph nodes increases probability of finding neoplastic involvement in relation to resection of fewer. Assess the presence of angiolymphatic invasion; perineural and intracelluar mucin and correlate it with tumor differentiation and TNM classification. Correlate the average of positive nodes with angiolymphatic and perineural involvement. Methods: Pathological reports of patients operated for CRC from 1997 to 2013 were analyzed. A probability ( p ) less than 0.05 was considered to indicate statistical significance. Results: Median of lymph nodes sent to analysis was 12 nodes. Average number of lymph nodes affected was higher when a number a?￥12 lymph nodes were dissected ( p = 0.001) (Kruskal-Wallis). There was positive association between average of affected lymph nodes and presence of angiolymphatic ( p < 0.0001) or perineural invasion ( p = 0.024). Angiolymphatic and intracellular mucin are less present in well-differentiated adenocarcinomas. Perineural and angiolymphatic were more present in T4 stages. Conclusions: Dissection a?￥12 lymph nodes increases chances of finding positive nodes. There is relation between angiolymphatic invasion; perineural and intracellular mucin and type of tumor differentiation, as well as TNM classification. Average number of lymph nodes affected was higher in presence of perineural or angiolymphatic invasion.