On the regulation of PP2A and its role in controlling sister chromatid cohesion and microtubule-kinetochore attachment

摘要

Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation of the cell cycle. PP2A is involved in such diverse processes by the formation of structurally distinct families of holoenzymes, which are regulated spatially and temporally by specific regulators. Mitosis requires the correct arrangement of sister chromatids so that replicated chromosomes can bind correctly to microtubules and segregate towards opposite poles. A large number of studies have shown that PP2A is mainly involved in a series of phosphorylation processes during the G2/M phase transition and the termination of M phase. Moreover, PP2A shows a more substantial contribution to sister chromatid cohesion and microtubule-kinetochore attachment. These processes are all crucial for proper cell survival and proliferation and are often deregulated in cancer and other diseases.