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Greater Arterial Stiffness in Polycystic Ovary Syndrome (PCOS) Is an Obesity- But Not a PCOS-Associated Phenomenon

机译:多囊卵巢综合征(PCOS)中的更大的动脉僵硬度是一种肥胖,但不是PCOS相关的现象

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Context: Polycystic ovary syndrome (PCOS) and obesity are associated with cardiovascular disease, but it is unclear to what extent they contribute independently. Arterial stiffness might link obesity and PCOS to cardiovascular diseases.Objective: Our objective was to investigate whether PCOS in the presence or absence of obesity is linked with arterial stiffness.Design and Setting: We conducted a cross-sectional study, including 31 obese (18 with PCOS) and 39 lean (22 with PCOS) women.Interventions and Main Outcome Measures: Estimates of arterial stiffness were obtained by ultrasonography (distensibility and compliance of carotid, femoral, and brachial arteries; carotid elastic modulus; and intima-media thickness) and pulse wave transit time analyses (carotid-femoral pulse wave velocity and aortic augmentation index).Results: Obese women, with or without PCOS, had stiffer arteries than lean women. After adjustment for 24-h mean arterial pressure and age, obesity was inversely associated with the femoral, brachial, and carotid distensibility coefficients [β (95% confidence interval), ?0.354 (?0.614 to ?0.094), ?0.354 (?0.547 to ?0.161), and ?0.248 (?0.370 to ?0.126) 10~(?3)/kPA, respectively] and with the femoral and carotid compliance coefficients [?0.296 (?0.563 to ?0.029) and ?0.190 (?0.377 to ?0.003) mm~(2)/kPA, respectively] but not with the brachial compliance coefficient [?0.018 (?0.052–0.015) mm~(2)/kPA], Young’s elastic modulus [0.049 (?0.005–0.103) kPA], aortic pulse wave velocity and aortic augmentation index [0.050 msec (?0.959–1.058 msec) and ?1.831% (?8.196–4.534%), respectively]. Analyses with waist circumference as key independent variable gave broadly similar results. In contrast, PCOS was not associated with arterial stiffness estimates after adjustment for the presence of obesity.Conclusions: In young obese women with PCOS, (central) obesity, rather than PCOS itself, is associated with increased arterial stiffness. These data emphasize that, from the perspective of cardiovascular risk reduction, the focus should be on central fat mass reduction in obese women with PCOS.
机译:背景:多囊卵巢综合征(PCOS)和肥胖与心血管疾病有关,但目前尚不清楚他们在多大程度上贡献。动脉僵硬可能将肥胖和pCOS联系到心血管疾病。目的是调查在存在或没有肥胖的情况下PCOS是否与动脉僵硬有关.Design和环境:我们进行了一个横断面研究,其中包括31个肥胖症(18用PCOS)和39 leas(22带PCOS)女性。Interventions和主要结果措施:通过超声检查获得动脉僵硬度(颈动脉,股骨和肱动脉的致密性和遵守;颈动脉弹性模量;和内部介质厚度)和脉冲波传输时间分析(颈动脉脉搏波速度和主动脉增强指数)。结果:肥胖女性,有或没有PCOS,比精益妇女更富有动脉。在调整24-h平均动脉压和年龄后,肥胖与股骨,肱骨和颈动脉和颈动脉和颈动脉的变性系数相反[β(95%置信区间),?0.354(?0.614至094),?0.354(?0.547到?0.161),分别为0.248(?0.370至0.126)10〜(α3)/ kPa,股骨和颈动脉合规系数[?0.296(?0.563至029)和?0.190(?0.377 [0.003)mm〜(2)/ kPa,但不具有肱准合规系数[η018(Δ0.052-0.015)mm〜(2)/ kPa],杨氏弹性模量[0.049(<0.005-0.103) KPA],主动脉脉搏波速度和主动脉增强指数[0.050毫秒(?0.959-1.058毫秒)和?1.831%(?8.196-4.534%)。随着腰围分析,作为关键独立变量,具有广泛相似的结果。相比之下,PCOS在调整肥胖症的情况下调整后的动脉僵硬估计与动脉僵硬估计无关。结论:在具有PCOS的年轻肥胖女性中,肥胖,而不是PCOS本身,与增加的动脉僵硬相关。这些数据强调,从心血管风险降低的角度来看,重点应该是肥胖妇女与PCOS中的中枢脂肪量减少。

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