AgRP and NPY Expression in the Human Hypothalamic Infundibular Nucleus Correlate with Body Mass Index, Whereas Changes in αMSH Are Related to Type 2 Diabetes

Anneke Alkemade; Chun-Xia Yi; Lei Pei; Magdalena Harakalova; Dick F. Swaab; Susanne E. la Fleur; Eric Fliers; Andries Kalsbeek

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AgRP and NPY Expression in the Human Hypothalamic Infundibular Nucleus Correlate with Body Mass Index, Whereas Changes in αMSH Are Related to Type 2 Diabetes

机译：人类下丘脑嗜睡中的AgRP和NPY表达与体重指数相关，而αmsh的变化与2型糖尿病有关

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Context:Rodent data show that altered hypothalamic signaling contributes to the development of obesity and insulin resistance.

机译：背景：啮齿动物数据显示，改变的下丘脑信号有助于肥胖和胰岛素抵抗的发展。

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《The journal of clinical endocrinology and metabolism》 |2012年第6期|共9页
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Anneke Alkemade; Chun-Xia Yi; Lei Pei; Magdalena Harakalova; Dick F. Swaab; Susanne E. la Fleur; Eric Fliers; Andries Kalsbeek;
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1. Pharmacological and molecular characterization of ATP-sensitive K(+) conductances in CART and NPY/AgRP expressing neurons of the hypothalamic arcuate nucleus. [J] . van-den-Top M, Lyons DJ, Lee K, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2007,第3期

机译：下丘脑弓状核的CART和NPY / AgRP表达神经元中ATP敏感K（+）电导的药理和分子表征。
2. Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. [J] . van den Top M, Lee K, Whyment AD, Nature neuroscience . 2004,第5期

机译：下丘脑弓状核中对氧敏感的NPY / AgRP起搏器神经元。
3. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. [J] . Cowley MA, Pronchuk N, Fan W, Neuron . 1999,第1期

机译：NPY，AGRP和黑皮质素信号在下丘脑室旁核中的整合：脂肪细胞的细胞基础的证据。
4. Effects of human leptin fragments in hypothalamic nucleus C-fos expression [C] . Vani X.Oliveira, M.Teresa M.Miranda, Jackson C.Bittencourt, the International Peptide Symposium . 2001

机译：人瘦素片段在下丘脑核C-FOS表达中的影响
5. Changes in serum lipids with change and fluctuation in body mass index and body fat distribution in Mexican Americans with type 2 diabetes. [D] . Wear, Mary Louise. 2001

机译：墨西哥裔2型糖尿病患者血清脂质的变化与体重指数和身体脂肪分布的变化和波动之间的关系。
6. Altered features of neurotransmitters: NPY α-MSH and AgRP in type 2 diabetic patients with hypertension [O] . Baoxin Li, Shuang Ma, Shuqin Guo, 2020

机译：2型糖尿病高血压患者神经递质的改变特征：NPYα-MSH和AgRP
7. AgRP and NPY expression in the human hypothalamic infundibular nucleus correlate with body mass index. Whereas changes in alpha-MSH are related to type 2 diabetes. [O] . Alkemade A., Yi C.X., Pei L., 2012

机译：人下丘脑漏斗核中AgRP和NPY的表达与体重指数相关。而α-MSH的变化与2型糖尿病有关。

AgRP and NPY Expression in the Human Hypothalamic Infundibular Nucleus Correlate with Body Mass Index, Whereas Changes in αMSH Are Related to Type 2 Diabetes

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