The association of myelination in the internal capsule with iron deposition in the basal ganglia in macaques: a magnetic resonance imaging study

摘要

Background: Iron plays a vital role in myelin synthesis and maintenance. A tight association between iron concentration and myelin content has been demonstrated in local brain regions; however, whether such a relationship exists between distant brain regions that are anatomically connected is largely unknown. Methods: We conducted an in vivo measurement of iron and myelin content in the brains of 8 young (mean age: 7.7 years) and 8 old (mean age: 24.7 years) macaques by integrating two MRI-based techniques: quantitative susceptibility mapping (QSM) and myelin water fraction (MWF) imaging. We examined the relationship between iron deposition in components of the basal ganglia (BG), and the myelin content of the BG-connecting fiber tract internal capsule (IC) and four more white matter (WM) structures, including the optic tract, and the genu, body, and splenium of the corpus callosum, which are anatomically separate from the BG. Results: Spearman’s correlation analysis revealed a moderate to high (r=0.528–0.808, P0.05) positive correlation between the magnetic susceptibility of the BG and the MWF of anatomically connected IC structures during myelin production and maintenance, but little significant correlation was found between the susceptibility of the BG and the MWF of WM structures not anatomically connected to the BG. Conclusions: These results advance the understanding of the relationship between iron and myelin, and suggest that future studies should consider the impact that iron concentration in the BG has on the myelination of WM structures that are anatomically connected to the BG.