Serological evidence of inter-epizootic/inter-epidemic circulation of Rift Valley fever virus in domestic cattle in Kyela and Morogoro, Tanzania

摘要

Author summary The RVFV maintenance between inter-epizootic/inter-epidemic periods is not fully understood, despite the widely hypothesized belief of maintenance via transovarially infected Aedes mosquito eggs. Increasing serological evidence however, suggests that there could be continuous virus circulation throughout these periods in domestic ruminants, wild animals and humans both in areas with and without known history of RVF outbreaks. In some countries, RVFV antibodies have been demonstrated in livestock raised in areas where no clinical disease has ever been reported. However, in Tanzania, RVFV antibodies in livestock have been demonstrated only in areas with history of RVF outbreaks, raising the question of whether the disease is not present, is overlooked due to lack of effective surveillance systems, or whether there are strains of RVFV with low pathogenicity that do not cause detectable clinical cases in non-outbreak areas. We report here inter-epizootic/inter-epidemic RVFV antibody prevalence in non-vaccinated cattle from areas with no previous RVF outbreak in Tanzania and demonstrate recent virus circulation by detection of IgM antibodies. The differences in RVFV seroprevalence in different study locations suggest local factors that favour the virus amplification and transmission within those areas.