Reply to Francescato et al.: on correct computation of confidence intervals for kinetic parameters

摘要

We thank Francescato and colleagues for their interest inour studies (Goulding et al., 2018a,b).Our decision to use the 1-sec interpolation method wasborne out of the data of Benson et al., (2017b). Theseauthors used 2*105 Monte Carlo simulations of moderate-intensity exercise transitions to determine the impactof various averaging and fitting procedures on sV_ O2estimation.A particular strength of this study was the abilityto produce a clean _V O2 kinetic trace with known (i.e.“true”) parameters. Subsequently, this trace was sampledusing simulations of breathing frequency and the additionof Gaussian noise similar to that associated with experimentallyobtained _V O2 data, but with known underlyingkinetic parameters. This study, therefore, represents theonly study which has allowed precise quantification ofboth the precision and the accuracy of _V O2 averagingmethods.