Flu Vaccine Coupled to Vitamin D Decrease the Frequency of Lower Respiratory Tract Infections (Randomized Controlled Trial)

摘要

>Introduction: style="font-family:""> style="font-family:Verdana;"> Influenza disease is one of the major health concerns in pediatrics. One of the style="font-family:Verdana;">most recently suggested effects of vitamin D is preventing infectious diseases. The aim of our study was to compare flu vaccine effect to flu vaccine associated to vitamin D (100 style="font-family:Verdana;">, style="font-family:Verdana;">000 style="font-family:""> style="font-family:Verdana;">UI style="font-family:""> style="font-family:""> style="font-family:Verdana;">per OS) in reducing respiratory tract infections in children. style="font-family:Verdana;">Patients and Methods: style="font-family:Verdana;"> 347 healthy children aged 2 to 5 years randomly selected during fall 2012 and the following season fall style="font-family:Verdana;">2013 were included; upper and lower respiratory tract infections following style="font-family:Verdana;"> vac style="font-family:Verdana;">cination were noted. Our results were analyzed using SPSS program (Chi-square > style="font-family:Verdana;">and T-test). style="font-family:Verdana;">Results: style="font-family:Verdana;"> Out of a total of 347 children included, 150 received flu style="font-family:Verdana;"> vac style="font-family:Verdana;">cine and 197 received flu vaccine plus vitamin D. 88 children from both style="font-family:Verdana;"> groups style="font-family:Verdana;">manifested upper respiratory tract infections and 64 had lower respiratory style="font-family:Verdana;">tract infections. The statistical analysis revealed no significant difference be style="font-family:Verdana;">tween the two groups concerning the upper respiratory tract infection (p style="font-family:""> style="font-family:Verdana;">= style="font-family:""> style="font-family:Verdana;">0.207) and a significant difference between groups for the lower respiratory tract infection (p style="font-family:""> style="font-family:Verdana;">= style="font-family:""> style="font-family:""> style="font-family:Verdana;">0.001). style="font-family:Verdana;">Conclusion: style="font-family:Verdana;"> Coupling vitamin D to flu vaccine provides no protection against upper respiratory infections but provides an effective strategy to decrease the rate of lower respiratory infections in children 2 style="font-family:""> style="font-family:Verdana;">- style="font-family:""> style="font-family:Verdana;">5 years of age.