Maternal exposure to fine particulate matter during pregnancy induces progressive senescence of hematopoietic stem cells under preferential impairment of the bone marrow microenvironment and aids development of myeloproliferative disease

摘要

During the last few decades, industrial development andexpansion have led to significantly increased levels of fineparticulate matter (PM) in the air, including particles withaerodynamic diameters smaller than 2.5 μm (referred to asPM2.5) [1]. PM2.5 can have negative effects on air qualityand threatens human health. Furthermore, it can have effectson tissue-specific stem progenitor cells [2, 3]. However,little is known about the mechanisms underlying the effectsof PM2.5 on stem progenitor cells, particularly hematopoietic stem progenitor cells (HSPCs). There is growingevidence that maternal exposure to PM2.5 during pregnancy can harm both the embryo and progeny [4–6]. The embryoand fetus are more susceptible to external stress than theadult. Although there is growing evidence regarding thedetrimental risks to the embryo and offspring that have beenmaternally exposed to PM2.5 during pregnancy [4–6], littleis known about the effects of maternal PM2.5 exposure tostem cells, which begin to emerge, activate, and matureduring embryo development.