Degenerative intervertebral disc disease evokes a common clinical problem which has major socio-economic impact in the developing and developed countries, but it is well known that restoration to the normal spine is impossible once the degeneration cascade has begun. Although there are many studies on this fundamental question with great effort by numerous research groups, most spine researchers agree that we are still lack of advanced convergence studies starting from the bench to bed and these researches should be continued consistently by a diversity of specialists.
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