Sulfur dioxide resistance in iSaccharomyces cerevisiae/i: beyond iSSU1/i

摘要

Sulfite resistance is an important oenological trait forwine yeasts because this compound is used duringwinemaking as a microbial inhibitor and antioxidant.The molecular mechanisms by which Saccharomycescerevisiae responds and tolerates SO2 have been mainlyfocused on the sulfite efflux pump encoded by SSU1.Different chromosomal rearrangements in the regulatoryregion of this gene have been correlated with improvedsulfite tolerance. However, other molecularfactors must contribute to this trait because the SSU1gene activity does not always fit with sulfite tolerance.An interesting approach to shed light onto this issuecould be found by Lage et al. (2019). These authorshave combined transcriptomic and genome-wide analysisto describe how the poorly characterized transcriptionfactor Com2 controls, directly or indirectly,the expression of more than 80% of the genes activatedby SO2. Additionally, large-scale phenotyping revealedthe identification of 50 Com2-targets contributingto the protection against SO2. This information isvery interesting for gaining knowledge regarding thisimportant industrial trait.