Taking the daily grind out of HIV prevention

摘要

Despite the proven efficacy of daily oral PrEP (pre-exposure prophylaxisagainst HIV infection) in high-risk populations like men whohave sex with men (MSM), injecting drug users, serodiscordant couples,and sex workers adherence and continuation rates decline over time,thereby reducing PrEP’s public health impact [1].Contributing to this decline, and to low levels of PrEP initiation,are the burden and stigma associated with taking a daily PrEP pill [2]or, for MSM only, a 2+1+1 on-demand oral regimen [3].Given the challenges associated with the current PrEP options,there is an urgent need to develop new user-friendly PrEP or PEP(post-exposure prophylaxis against HIV infection) dosage forms anddosing regimens.