Assessment of the Effect of Mannitol on Intracranial Pressure, Cerebral Perfusion Pressure, Systemic and Central Hemodynamics in Patients with Isolated Traumatic Brain Injury

摘要

Severe TBI leads to cerebral edema, increased ICP, resulting in decreased cerebral perfusion pressure and increased secondary ischemic injury. Appropriate and timely treatment of elevated ICP improves cerebral perfusion to reduce this secondary ischemic stroke. Mannitol is currently a widely used diuretic for the treatment of ICH and is recommended in guidelines for the treatment of TBI in adults. The aim of the study : to study the effect of early prescription of 15% mannitol solution on the studied parameters of systemic, central hemodynamics, homeostasis, ICP and CPP, to determine its effectiveness and safety in the adult population with TBI. Research methods: A total of 30 patients were included in this study, conducted over 3 years (2017-19) in the departments of neurosurgery and anesthesia and resuscitation of the TMA. Conclusion: therefore, it can be concluded that the rate of infusion may depend on the duration of the action of mannitol, because the faster the infusion, the greater the likelihood of termination of the effect due to rapid excretion of mannitol by the kidneys or its penetration into the brain tissue.