Clinical and Laboratory Characteristics of Patients with Hepatocellular Carcinoma Associated with Viral Hepatitis B

摘要

The presence of cirrhosis increases the risk of developing hepatocellular carcinoma by more than 30 times compared with patients without cirrhosis. Such a high risk of developing primary liver cancer is due to the fact that cirrhosis is the final stage in the progression of a large number of lesions and liver diseases. It should be borne in mind that in most patients, cirrhosis of the liver is compensated in nature and, accordingly, is asymptomatic. In such cases, the onset of symptoms and, accordingly, the diagnosis of the disease occurs either at the onset of the decompensation phase of liver cirrhosis, or when signs of neoplasm appear. The work included data from a retrospective and prospective analysis of case histories of patients diagnosed with hepatocellular carcinoma who were hospitalized at the Republican Specialized Scientific and Practical Medical Center for Oncology and Radiology of the Republic of Uzbekistan from 2016 to 2019. 68 Patients were divided into 2 groups. The main group consisted of patients with hepatocellular carcinoma and positive tests for HBsAg. The control group included patients with hepatocellular carcinoma, in which serological markers for viral hepatitis were negative. This is due to the direct participation of the hepatitis B virus itself in the development of oncogenesis of hepatocellular carcinoma. In addition, the clinical picture consists of the symptoms of the oncological process on the one hand and the clinical picture of a prolonged viral liver damage, on the other hand.