Ordinal Regression Modeling of Mother to Infant HIV Transmission in Nyeri County, Kenya

摘要

The transmission rates of HIV from a HIV-positive mother to her child during pregnancy, delivery or breastfeeding remains of much concern. Various governments and non-governmental organizations have aimed at coming up with policies aimed at minimizing the transmissions. For this to be achievable, there is a need for sound statistical procedures in the analysis of the mother to infant HIV transmission data. The study gives an application of the ordinal regression to the modeling of such data, a case of Nyeri County-Kenya. The logistic regression has been described as the best methodology for modeling binary response variables. However it does not provide a best fit for an ordered categorical variable with more than two categories. This calls for the extensions of the logistic regression which can be used when modeling such kind of variables, such an extension is the ordinal regression methodology. This study proposes the use of the ordinal regression methodology with probit and logit link functions to model infant feeding, arv regimen, maternal cell count and maternal viral load effect on mother to infant HIV transmission in Nyeri county, Kenya a case of Karatina sub-county referral hospital. An aspect of the ordinal link models, which can be useful for this implementation is particularly emphasized as it is in their interpretation that the classes of the dependent variable can be considered from the partition of the variation interval of an underlying continuous random variable. Data to be used shall be secondary data collected from Karatina sub-county referral hospital. Inference on parameters and model diagnostics is also provided.