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Cough sound analysis and objective correlation with spirometry and clinical diagnosis

机译:咳嗽声学分析及肺活量测定和临床诊断的客观相关性

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摘要

In India, there are 100 million people who suffer from various respiratory problems; globally it is about 1–1.2 billion. The main problem attributed to the prevalence of respiratory diseases is lack of cost-effective and lab-free methods for early diagnosis. Spirometry is the standard clinical test procedure for detection of respiratory problems, but it requires repetition, and is also expensive and not available in rural areas. Cough sounds carry vital information about the respiratory system and the pathologies involved. Through this study, we detail how a combination of standard signal processing features and domain-specific features play a key role in distinguishing cough patterns. We could establish a relationship between cough pattern and respiratory conditions including widened airway, narrowed airway, fluid filled air sacs, and stiff lungs. Further, cough sound characteristics are correlated to the airflow parameters of spirometry. Our results show strong correlation of cough sound characteristics with airflow characteristics including FEV1, FVC and their ratios, which are important in identifying the type of lung diseases as either obstructive (obstruction in airway) or restrictive (restricts lung expansion). We have constructed a machine learning model to predict obstructive versus restrictive pattern, and validated it using K-fold cross-validation based on ground truth data. With a pattern prediction accuracy of 91.97%, sensitivity of 87.2%, and specificity of 93.69%, our results are encouraging.
机译:在印度,有100万人患有各种呼吸问题;全球范围内约为1-12亿。归因于呼吸系统疾病患病率的主要问题是早期诊断缺乏成本效益和无实验室的方法。肺活量测量是检测呼吸问题的标准临床试验程序,但需要重复,并且在农村地区也是昂贵的,并且在农村地区不可用。咳嗽声音携带有关呼吸系统和所涉及的病理的重要信息。通过本研究,我们详细介绍了标准信号处理特征和域特定功能的组合如何在区分咳嗽模式中发挥关键作用。我们可以建立咳嗽模式和呼吸状况之间的关系,包括加宽的气道,气道,液体填充的气囊和僵硬的肺部。此外,咳嗽声特性与肺炎的气流参数相关。我们的结果表明,咳嗽声特性与气流特性的强烈相关性,包括FEV1,FVC及其比例,这对于鉴定肺病类型作为阻塞性(气道的阻塞)或限制(限制肺扩增)。我们已经构建了一种机器学习模型来预测阻塞性与限制性模式,并使用基于地面真理数据的k折交叉验证验证。模式预测精度为91.97%,敏感性为87.2%,特异性为93.69%,我们的结果令人鼓舞。

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