Associa??es de polimorfismos IL-6 -174GC e IL-10 -1082AG com suscetibilidade à doen?a celíaca: evidências de uma meta-análise e revis?o de literatura

摘要

BACKGROUND: There has been little evidence to suggest that the IL-6 -174GC and IL-10 -1082AG polymorphisms are significantly associated with susceptibility to celiac disease. Thus, we performed the present meta-analysis to explore the potential association between these polymorphisms and celiac disease risk. METHODS: Eligible studies were searched in PubMed, Medline, Embase, Web of Science and CNKI database up to April 20, 2019. Odds ratios with 95% confidence interval were calculated to assess the potential associations. Moreover, we performed the heterogeneity, sensitivity, and publication bias tests to clarify and validate the pooled results. RESULTS: Overall, nine case-control studies involving five studies with 737 cases and 1,338 control on IL-6 -174GC polymorphism and four studies with 923 cases and 864 controls on IL-10 -1082AG polymorphism were selected. The pooled ORs showed that the IL-6 -174GC and IL-10 -1082AG polymorphisms were not significantly associated with increased risk of celiac disease under all five genetic models. There was no publication bias. CONCLUSION: To the best of our knowledge, this is the first meta-analysis summarizing all of the available studies on the association of IL-6 -174GC and IL-10 -1082AG polymorphisms with celiac disease. Our results suggest that the IL-6 -174GC and IL-10 -1082AG polymorphisms may not be associated with increased risk of celiac disease. Moreover, large and well-designed studies are needed to fully describe the association of IL-6 -174GC and IL-10 -1082AG polymorphisms with celiac disease.