Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis

摘要

PurposeTo describe a case of corneal ulceration associated with dupilumab use for atopic dermatitis.ObservationsA patient developed an inflammatory corneal ulcer 3 weeks after starting bi-weekly intravenous dupilumab therapy. Symptoms resolved with topical prednisolone and discontinuation of the systemic therapy with dupilumab.Conclusion and importanceDupilumab is known to cause ocular surface inflammation, but we report a novel association between dupilumab use and potentially sight-threatening corneal ulceration.