Association between the NOS2 pentanucleotide repeat polymorphism and risk of postoperative recurrence of chronic rhinosinusitis with nasal polyps in a Japanese population

摘要

Limitation should be noted in the present study. First, most of the patients were those with ECRS, and it is difficult to reach a valid conclusion with small sample size for non-ECRS. Second, few studies have been conducted to examine the relationship between CRSwNP and NOS2 pentanucleotide repeats polymorphisms. So far, two studies have been performed to examine the association be- tween the NOS2 pentanucleotide repeats polymorphisms and the presence of NP.* In contrast to our results, the results of both of those studies showed that the presence of NP gradually increased as the pentanucleotide repeat numbers increased. However, those studies did not report on the status of chronic rhinosinusitis or the clinical prognosis, therefore, it is unclear whether different environmental backgrounds and phenotypes examined may result in an inverted association.