Scanning Electron Microscopic Study of the Anthelmintic Effects of Some Anthelmintic Drugs on Poultry Nematode, Ascaridia galli

摘要

Praziquantel/pyrantel pamoate (PZQ/PTP) combination and albendazole (ABZ) are two commercially available anthelmintic drugs most commonly used for the treatment of different helminth infections. Their anthelmintic activity was studied in vitro against the poultry nematode, Ascaridia galli. Although both the drugs were effective, ABZ showed most prominent activity. Scanning electron microscopy of the nematodes revealed structural damaged induced by the drugs. Shrinkage of the cuticle, collapse of the lips, and formation of cuticular folds were the defining anthelmintic effects. Comparison based the drug efficacy and anthelmintic effects indicates that ABZ can be the drug of choice for helminthiasis due to nematodes.