首页> 外文期刊>Communications Biology >Social and non-social autism symptoms and trait domains are genetically dissociable
【24h】

Social and non-social autism symptoms and trait domains are genetically dissociable

机译:社会和非社会自闭症症状和特质域在转基因上可解释

获取原文
       

摘要

The core diagnostic criteria for autism comprise two symptom domains – social and communication difficulties, and unusually repetitive and restricted behaviour, interests and activities. There is some evidence to suggest that these two domains are dissociable, though this hypothesis has not yet been tested using molecular genetics. We test this using a genome-wide association study (N = 51,564) of a non-social trait related to autism, systemising, defined as the drive to analyse and build systems. We demonstrate that systemising is heritable and genetically correlated with autism. In contrast, we do not identify significant genetic correlations between social autistic traits and systemising. Supporting this, polygenic scores for systemising are significantly and positively associated with restricted and repetitive behaviour but not with social difficulties in autistic individuals. These findings strongly suggest that the two core domains of autism are genetically dissociable, and point at how to fractionate the genetics of autism. Varun Warrier et al. report a genome-wide association study of systemising, a non-social trait associated with autism. They find 3 loci associated with systemising and show that this trait has no significant genetic correlations to social phenotypic measures, demonstrating that the social and non-social aspects of autism are genetically distinct.
机译:自闭症的核心诊断标准包括两个症状域 - 社会和沟通困难,异常重复和受限制的行为,利益和活动。有一些证据表明这两个结构域是可解释的,尽管该假设尚未使用分子遗传学测试。我们使用与自闭症有关的非社会特征的基因组 - 范围协会研究(n = 51,564)测试这一点,被定义为分析和构建系统的驱动器。我们证明系统化与自闭症有遗传和遗传相关。相比之下,我们不确定社会自闭症性状与系统化之间的显着遗传相关性。支持这一点,用于系统化的多基因分数与受限制和重复的行为有显着和正相关,而是在自闭症中具有社会困难。这些调查结果强烈表明,自闭症的两个核心域在转基督上是基因上可解释的,并且如何分解自闭症的遗传学。 Varun Warrier等。报告了系统化的基因组协会研究,与自闭症相关的非社会特征。他们发现3个与系统化相关的基因座,表明这种特质与社会表型措施没有明显的遗传相关性,表明自闭症的社会和非社会方面是基因上的。

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号