Study of Cardiac Troponin I level in Acute Coronary Syndrome and its correlation with Left Ventricular Systolic Function

摘要

Background: In the diagnosis of acute coronary syndrome, cardiac troponin I is highly reliable andwidely available biomarker. Serum level of cardiac troponin I is related to amount of myocardialdamage and also closely relates to infarct size. Our aim of the study is to find out the relationshipbetween cardiac troponin I and left ventricular systolic function after acute coronary syndrome.Methods: Total of 132 acute coronary syndrome patients were included in this study after admissionin coronary care unit of Sir Salimullah Medical College, Mitford Hospital. Troponin I level wasmeasured at admission and left ventricular ejection fraction (LVEF) was measured byechocardiography between 12-48 hours of onset of chest pain.Results: There was negative correlation between Troponin I at 12 to 48 hours of chest pain withLVEF in these study patients. With a cutoff value of troponin I e”6.8 ng/ml in STEMI patients thereis a significant negative relation between 12 to 48 hrs troponin I and LVEF (p0.001). Sensitivity oftroponin I e” 6.8 ng/ml between 12 to 48 hours of chest pain in predicting LVEF 50% in STEMI was93.75% and specificity was 77.78%. In NSTEMI sensitivity of troponin I e” 4.5 ng/ml between 12 to48 hours of chest pain in predicting LVEF 50% was 65% and specificity was 54.05%.Conclusion: Serum troponin I level had a strong negative correlation with left ventricular ejectionfraction after acute coronary syndrome and hence can be used to predict the LVEF in this setting.