Factors Associated with Bothersome Lower Urinary Tract Symptoms in Middle-Aged Men Receiving Health Checkup

摘要

The prospective study is to investigate the associations between serum testosterone levels and LUTS among middle-aged men ≥40 years receiving health check-up. Lower urinary tract symptoms were evaluated by the self-administered International Prostate Symptom Score questionnaire. Serum prostate specific antigen and total testosterone level were checked in all subjects. A total of 1752 men were enrolled into the study. The mean age was 55.6?±?9.7 years. All study subjects were stratified into low, medium and high testosterone levels by two cut-off, 3.0 and 4.11?ng/mL. We found that testosterone levels were significantly associated with metabolic syndrome and body fat components. Compared to those with low testosterone levels, subjects with high and medium testosterone had a significantly higher IPSS (5.84?±?5.55 vs 6.71?±?5.68 and 6.34?±?5.66, p?=?0.032) and storage score (2.76?±?2.29 vs 3.20?±?2.49 and 2.90?±?2.49; p?=?0.009), and a more moderate/severe LUTS (IPSS?≧?8) (26.5% vs 35.7% and 29.9%; p?=?0.002). Multivariate analyses showed that high vs low testosterone levels (OR, 1.76; 95% CI, 1.26-2.45) and prostate volume ≧25 vs 25?mL (OR, 1.38; 95% CI, 1.04-1.82) significantly associated with the presence of moderate/severe LUTS. Pearson correlation analyses showed significantly positive correlations between testosterone level and IPSS in whole study sample (Pearson correlation coefficient, 0.066; p??0.01) and in the subgroup of moderate/severe LUTS (Pearson correlation coefficient, 0.038; p??0.05). In conclusion, high testosterone and prostate volume adversely impacted LUTS in our target population.