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首页> 外文期刊>Scientific reports. >Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
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Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

机译:缩小翻译鸿沟:在具有疾病相关同源基因突变的小鼠和人类中进行相同的认知触摸屏测试

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Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.
机译:缺乏转化性认知测试方法阻碍了针对脑部疾病的有效疗法的发展。我们提供了使用基于触摸屏的相同认知测试来评估携带疾病相关基因突变的小鼠和人类的第一个例子。这一新范例对改善我们如何测量和建模动物人类疾病中的认知功能障碍具有重要意义,从而弥合了有效翻译到临床的空白。

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