Comparison of Vitamin D Levels in Pre-eclamptic and Normotensive Pregnant Women in a Tertiary Care Centre

摘要

Pre-eclampsia is a multi-system disorder of pregnancy that is significantly contributes to maternal and fetal morbidity and mortality rates. The aetiology of pre-eclampsia remains unknown. Besides other risk factors, attention has been drawn towards vitamin D deficiency as a causative factor for pre-eclampsia.Aim: To compare vitamin D levels in pre-eclampsia and normotensive pregnant women.Materials and Methods: A prospective comparative study was conducted in the Department of Obstetrics and Gynaecology, Adesh Institute of Medical Sciences and Research (AIMSR), Bathinda, Punjab, India from January 2017 to October 2018. Thirty pregnant women with pre-eclampsia were compared with equal number of normotensive pregnant women for serum vitamin D levels. MS Excel 2010 software was used to analyse the data. Quantitative data were expressed as a mean±standard deviation.Results: It was observed that vitamin D deficiency was invariably present in all pregnant women but the mean vitamin D level was significantly lower in Pre-eclampsia group as compared to Control group (8.7±5.32 and 14.2±7.88 ng/mL respectively) with p<0.05 which was statistically significant.Conclusion: The present study revealed significant association between maternal serum vitamin D deficiency and occurrence of pre-eclampsia. Vitamin D supplements should be added to all the antenatal patients as routine screening to prevent the risk of pre-eclampsia.