Pseudomyxoma Peritonei (PMP) is a rare, chronic, poorly understood disease that is characterized by disseminated mucinous ascitis and peritoneal implants. In order to diagnose PMP, viable epithelial glandular cells must be identified within the mucinous pools by histological analysis. We report here, two male patients and one female patient who presented to our hospital within a span of 4 months. Histopathology records of the last 10years do not reveal any case of PMP. In case1, the diagnosis of PMP was made after laparotomy, as the radiological findings suggested hollow viscus perforation. The case 2 patient had second debulking surgery after 11 years. The case 3 patient developed PMP 3 years after the first surgery. In this patient, preoperative diagnosis was made due to the typical CT findings and appendicial origin was confirmed by CK 7 negativity. All three patients underwent debulking surgery and were referred to the Oncology department for further treament. Histopathology reports of case 1 and case 3 revealed benign epithelium, whereas case 2 had foci of borderline epithelium, indicating disease progression. All three were symptom free after a short follow up of one, two and three months in case 1, 3 and 2, respectively. In all the three cases, PMP was secondary to tumours of the appendix.
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