Parallel Evaluation of the MALDI Sepsityper and Verigene BC-GN Assays for Rapid Identification of Gram-Negative Bacilli from Positive Blood Cultures

摘要

Bloodstream infections (BSIs) are an important cause of morbidity and mortality (1). Following the onset of sepsis-related hypotension, mortality rate increases nearly 8% for every hour that effective antimicrobial therapy is delayed (2). Therefore, rapid identification (ID) of the causative agent and antimicrobial susceptibility testing (AST) are important to improve patient outcome. Routine microbiology methods rely on subculture of positive blood cultures to solid medium and require 18 to 48 h, or more, from initial blood culture positivity to definitive bacterial ID and AST. To address this challenge, several diagnostic systems have been developed and marketed for rapid ID of organisms found in positive blood cultures (3, 4).