Pursuing a ‘turning point’ in growth cone research

摘要

Growthconesarehighlymotilestructuresfoundattheleadingedgeofdevelopingandregeneratingnerveprocesses.Theirroleinaxonalpathfindinghasbeenwellestablishedandmanyguidancecuesthatinfluencegrowthconebehaviorhavenowbeenidentified.Manystudiesarenowprovidinginsightsintothetransductionandintegrationofsignalsinthegrowthcone,thoughafullunderstandingofgrowthconebehaviorstilleludesus.Thisreviewfocusesonrecentstudiesaddingtothegrowingbodyofliteratureongrowthconebehavior,focusingparticularlyonthelevelofautonomythegrowthconepossessesandtheroleoflocalproteinsynthesis./p/div