The Murine Gene, Traube, Is Essential for the Growth of Preimplantation Embryos

Tim Thomas; Anne K. Voss; Petros Petrou; Peter Gruss

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The Murine Gene, Traube, Is Essential for the Growth of Preimplantation Embryos

机译：鼠基因Traube对植入前胚胎的生长至关重要

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Littleisknownaboutthegeneticcontrolofpreimplantationdevelopment.Wehaveisolated,characterized,andmutatedapreviouslyundescribedmousegene,emTraube(Trb),/emessentialforpreimplantationdevelopment.Similarproteincodingsequencesarefoundinrats,humans,andyeast.TheTRBproteincontainedtwoamino-terminalacidicdomains,aleucinezipper,andthreeputativenuclearlocalizationsignals.TheemTrb/emgenewasexpressedatlowlevelsubiquitouslyearlyindevelopmentandbecamerestrictedtotheliverandthecentralnervoussystemfromE11.5onward.Myc-taggedTRBproteinwaslocalizedtothenucleus,andinalargeproportionofthecellstothenucleoli.TheemTrb/emmutantembryoshaltedindevelopmentatthecompactedmorulastageatE2.5.AtE3.5theystartedtodecompactandadaylatertheydisintegratedanddied.Theobserveddefectwascellautonomous,asmutantcellsfailedtoparticipateintheformationofchimericembryos.TheemTrb/emmutantembryosshoweda50%reductionofthetotalcellnumber.Themutantembryosexhibitedapaucityofribosomes,polyribosomes,androughendoplasmicreticulum.ThispaucityofribosomestogetherwiththelocalizationofTRBtothenucleoli,thesiteofribosomesynthesis,suggeststhatTRBisinvolvedinthesynthesisofribosomes./p/div

机译：Littleisknownaboutthegeneticcontrolofpreimplantationdevelopment.Wehaveisolated，其特征在于，andmutatedapreviouslyundescribedmousegene，特劳贝（TRB）， essentialforpreimplantationdevelopment.Similarproteincodingsequencesarefoundinrats，人类，andyeast.TheTRBproteincontainedtwoamino-terminalacidicdomains，aleucinezipper，andthreeputativenuclearlocalizationsignals.The Trb的 genewasexpressedatlowlevelsubiquitouslyearlyindevelopmentandbecamerestrictedtotheliverandthecentralnervoussystemfromE11.5onward.Myc -taggedTRBproteinwaslocalizedtothenucleus，andinalargeproportionofthecellstothenucleoli.The Trb的 mutantembryoshaltedindevelopmentatthecompactedmorulastageatE2.5.AtE3.5theystartedtodecompactandadaylatertheydisintegratedanddied.Theobserveddefectwascellautonomous，asmutantcellsfailedtoparticipateintheformationofchimericembryos.The Trb的 mutantembryosshoweda50％reductionofthetotalcellnumber.Themutantembryosexhibitedapaucityofribosomes，多核糖体，androughendoplasmicreticulum.Th核糖体与核糖体的定位有关，核糖体的合成位点少，这建议TRB参与核糖体的合成。 展开▼

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《Developmental biology》 |2000年第2期|共页

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Tim Thomas; Anne K. Voss; Petros Petrou; Peter Gruss;
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中图分类生物科学;

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1. The murine gene, Traube, is essential for the growth of preimplantation embryos [J] . Thomas T., Petrou P., Gruss P., Developmental biology . 2000,第2期

机译：鼠基因Traube对植入前胚胎的生长至关重要

2. Selection of theIn VitroCulture Media Influences mRNA Expression of Hedgehog Genes,Il-6,and Important Genes regarding Reactive Oxygen Species in Single Murine Preimplantation Embryos [J] . N.Pfeifer, D. M.Baston-Büst, J.Hirchenhain, ScientificWorldJournal . 2012,第3期

机译：选择体外培养基的选择对刺猬基因，IL-6和重要基因的MRNA表达对单谷植入胚胎中的反应性氧物种

3. Expression pattern of zygote arrest 1 (ZAR1), maternal antigen that embryo requires (MATER), growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) genes in ovine oocytes and in vitro-produced preimplantation embryos [J] . Daniela Bebbere Luisa Bogliolo Federica Ariu Stefano Fois Giovanni Giuseppe Leoni Silvia Tore Sara Succu Fiammetta Berlinguer Salvatore Naitana and Sergio Ledda Reproduction, Fertility and Development . 2008,第8期

机译：合子停滞1（ZAR1），胚胎需要的母体抗原（MATER），生长分化因子9（GDF9）和骨形态发生蛋白15（BMP15）基因在绵羊卵母细胞和体外产生的植入前胚胎中的表达模式

4. Dynamic Imaging of Preimplantation Embryos in the Murine Oviduct [C] . Jason C. Burton, Shang Wang, Irina V. Larina Conference on optical methods in developmental biology . 2015

机译：小鼠输卵管植入前胚胎的动态成像

5. Individual bull variations on sperm acrosome reaction, sperm -zona binding, in-vitro embryo production, and preimplantation embryo apoptosis and gene expression [D] . Giritharan, Gnanaratnam 2004

机译：公牛对精子顶体反应，精子-zona结合，体外胚胎产生以及植入前胚胎凋亡和基因表达的变异

6. Selection of the In Vitro Culture Media Influences mRNA Expression of Hedgehog Genes Il-6 and Important Genes regarding Reactive Oxygen Species in Single Murine Preimplantation Embryos [O] . N. Pfeifer, D. M. Baston-Büst, J. Hirchenhain, 2012

机译：体外培养基的选择影响单个小鼠植入前胚胎中刺猬基因Il-6和有关活性氧物种的重要基因的mRNA表达

7. The Murine Gene, Traube, Is Essential for the Growth of Preimplantation Embryos [O] . Thomas Tim, Voss Anne K., Petrou Petros, 2000

机译：鼠基因Traube对植入前胚的生长至关重要

1. 人输卵管胚胎营养因子对着床前鼠胚胎基因表达的影响 [J] . 姚元庆 ,李启辉 ,许嘉森 . 中华妇产科杂志 . 2007,第009期

2. 胚胎植入前无创基因检测对胚胎染色体异常的筛查效能研究 [J] . 唐大伟 ,金锐 ,李小东 . 中国性科学 . 2020,第009期

3. 胚胎植入前基因检测技术在体外受精-胚胎移植中的应用现状 [J] . 李太旸 ,李蓉 ,王海燕 . 生殖与避孕 . 2020,第011期

4. 基于微阵列比较基因组杂交技术的胚胎植入前遗传学诊断和筛查在不同阶段胚胎中的临床应用结局分析 [J] . 沈鉴东 ,吴畏 ,舒黎 . 中华妇产科杂志 . 2017,第012期

5. 人类基因编辑实验的法律规制——兼论胚胎植入前基因诊断的法律议题 [J] . 王康 . 东方法学 . 2019,第001期

6. 高通量基因测序植入前胚胎遗传学诊断和筛查技术规范 [C] . 中华医学会生殖医学分会第四届委员会 . 中华医学会生殖医学分会指南共识研讨会 . 2018

7. 甜菜碱对孕前灌酒雌鼠早期植入前胚胎H3K9乙酰化水平的影响 [A] . 丁芳 . 2015

1. 一种胚胎植入前的基因学评估系统 [P] . 中国专利： CN108570411A . 2018-09-25

2. 胚胎植入前遗传性耳聋基因检测用引物组合物、试剂盒及应用 [P] . 中国专利： CN109055532A . 2018-12-21

3. METHOD OF PRODUCING BIOLOGICAL MATERIAL TRANSFERRED FOR GENETIC RESEARCH IN PROGRAMS OF PREIMPLANTATION GENETIC TESTING OF HUMAN EMBRYOS [P] . 外国专利： RU2718903C1 . 2020-04-15

机译：在人类胚胎植入前基因测试计划中进行遗传研究的生物材料的生产方法

4. METHOD FOR TROPHOBLAST CELLS BIOPSY AT MULTIPLICITY OF CELLS THAT DO NOT PARTICIPATE IN COMPACTION AT BLASTOCYST STAGE FOR HUMAN EMBRYOS PREIMPLANTATION GENETIC SCREENING PROGRAMMES [P] . 外国专利： RU2613788C1 . 2017-03-21

机译：在人类胚胎植入前遗传筛查程序中，在不参与细胞增殖的细胞的多重性中滋养细胞活细胞的方法

5. METHOD FOR DISCRIMINATION OF SEX IN MURINE AND BOVINE EMBRYO UTILIIZNG GENE HAVING SEXUAL DIFFERENCE IN EXPRESSION [P] . 外国专利： JPH06319546A . 1994-11-22

机译：在表达中存在性差异的鉴别鼠和牛胚胎生殖基因中性的方法。

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The Murine Gene, Traube, Is Essential for the Growth of Preimplantation Embryos

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