Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons

Manuel F. Batista; Jeffrey Jacobstein; Katharine E. Lewis

首页> 外文期刊>Developmental biology >Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons

【24h】

Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons

机译：斑马鱼V2细胞发展成兴奋性CiD和Notch信号依赖型抑制性VeLD中神经元

获取原文

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

团队文献服务 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Thevertebratespinalcordcontainsdistinctclassesofcellsthatformatprecisedorsalndash;ventrallocationsandexpressspecificcombinationsoftranscriptionfactors.Inamniotes,V2cellsdevelopintheventralspinalcord,justdorsaltomotoneurons.AllV2cellsdevelopfromthesameprogenitordomainandhenceareinitiallymolecularlyidentical.However,astheystarttobecomepost-mitoticanddifferentiatetheysubdivideintotwointermingledmolecularly-distinctsubpopulationsofcells,V2aandV2bcells.HereweshowthatthemolecularidentitiesofV2aandV2bcellsareconservedbetweenzebrafishandamniotes.Inzebrafish,thesetwocelltypesbothdevelopintointerneuronswithverysimilarmorphologies,butwhileV2acellsbecomeexcitatoryCircumferentialDescending(CiD)interneurons,V2bcellsbecomeinhibitoryVentralLateralDescending(VeLD)interneurons.Inaddition,wedemonstratethatNotchsignallingisrequiredforV2cellstodevelopintoV2bcells.IntheabsenceofNotchsignalling,allV2bcellsdevelopasV2acells./p/div

机译：Thevertebratespinalcordcontainsdistinctclassesofcellsthatformatprecisedorsalndash; ventrallocationsandexpressspecificcombinationsoftranscriptionfactors.Inamniotes，V2cellsdevelopintheventralspinalcord，justdorsaltomotoneurons.AllV2cellsdevelopfromthesameprogenitordomainandhenceareinitiallymolecularlyidentical.However，astheystarttobecomepost-mitoticanddifferentiatetheysubdivideintotwointermingledmolecularly-distinctsubpopulationsofcells，V2aandV2bcells.HereweshowthatthemolecularidentitiesofV2aandV2bcellsareconservedbetweenzebrafishandamniotes.Inzebrafish，thesetwocelltypesbothdevelopintointerneuronswithverysimilarmorphologies，butwhileV2acellsbecomeexcitatoryCircumferentialDescending（CID）的interneurons，V2bcellsbecomeinhibitoryVentralLateralDescending（草原）interneurons.Inaddition，wedemonstratethatNotchsignallingisrequiredforV2cellstodevelopintoV2bcells.IntheabsenceofNotchsignalling，allV2bcellsdevelopasV2acells

著录项

来源
《Developmental biology 》 |2008年第2期| 共页
作者
Manuel F. Batista; Jeffrey Jacobstein; Katharine E. Lewis;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类生物科学 ;
关键词

相似文献

外文文献
中文文献
专利

1. Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons. [J] . Batista MF, Jacobstein J, Lewis KE Developmental biology . 2008 ,第2期

机译：斑马鱼V2细胞发展成兴奋性CiD和Notch信号传导依赖性抑制VeLD间神经元。
2. LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. [J] . Joshi K, Lee S, Lee B, Neuron . 2009 ,第6期

机译：LMO4控制兴奋性和抑制性脊髓V2神经元之间的平衡。
3. Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. [J] . Yang X, Tomita T, Wines Samuelson M, Developmental Neuroscience . 2006 ,第1a2期

机译：Notch1信号传导影响脊髓中的v2神经元和运动神经元发育。
4. Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit [C] . Francisco J. Alvarez, Ana Benito-Gonzalez, Valerie C. Siembab Cellular and Network Functions in the Spinal Cord (Conference) . 2013

机译：renshaw细胞和运动神经元经常性抑制回路中学到的Interecoon开发原则
5. The effect of enforced Notch signaling on TCR beta, positive, and negative selection of developing T cells. [D] . Huang, Eugene Yukai. 2003

机译：强制的Notch信号对TCRβ，发育中的T细胞的阳性和阴性选择的影响。
6. LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons [O] . Kaumudi Joshi, Seunghee Lee, Bora Lee, -1

机译：LmO4控制兴奋和抑制脊椎V2的interneurons之间的平衡
7. Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons [O] . Batista Manuel F., Jacobstein Jeffrey, Lewis Katharine E. 2008

机译：斑马鱼V2细胞发展成兴奋性CiD和Notch信号依赖的抑制性VeLD间神经元

Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons

摘要

著录项

相似文献

相关主题

期刊订阅