TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors

Michelle L. Brinkmeier; Mary Anne Potok; Shannon W. Davis; Sally A. Camper

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TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors

机译：TCF4缺乏症会扩大腹侧间脑信号传导并增加垂体祖细胞的诱导

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TheanteriorandintermediatelobesofthepituitaryglandareformedfromRathkersquo;spouch.FGF,BMPandWNTsignalsemanatingfromtheventraldiencephaloninfluencepouchgrowthanddevelopment.InordertoexaminetheroleofcanonicalWNTsignalingduringpituitarydevelopmentweexaminedthepituitaryexpressionoftheTCF/LEFfamilyoftranscriptionfactors,whichmediateWNTsignalingthroughthebindingofβ-catenin.Wereportheretheexpressionofseveralmembersofthisfamilyduringpituitarydevelopmentandthefunctionalroleofonemember,TCF4(TCF7L2),intheinductionofthepituitaryprimordium.TCF4isexpressedintheventraldiencephalonearlyinpituitarydevelopment,rostraltoadomainofBMPandFGFexpression.emTcf4/emdeficientmiceexpressemFgf10/emandemBmp4/em;however,theemBmp/emandemFgf/emexpressiondomainsareexpandedrostrally.Asaresult,additionalpituitaryprogenitorcellsarerecruitedintoRathkersquo;spouchinemTcf4/emmutants.MutantsalsoexhibitanexpansionoftheemSix6/emexpressiondomainwithinRathkersquo;spouch,whichmayincreasethenumberofproliferatingpouchcells,resultinginagreatlyenlargedanteriorpituitarygland.ThissuggeststhatTCF4negativelyregulatespituitarygrowththroughtwomechanisms.ThefirstmechanismistorestrictthedomainsofBMPandFGFsignalingintheventraldiencephalon,andthesecondmechanismistherestrictionofemSix6/emwithinRathkersquo;spouch.Thus,TCF4isnecessarybothintrinsicallyandextrinsicallytoRathkersquo;spouchtoensurethepropergrowthofthepituitarygland./p/div

机译：TheanteriorandintermediatelobesofthepituitaryglandareformedfromRathkersquo ;. Spouch.FGF，BMPandWNTsignalsemanatingfromtheventraldiencephaloninfluencepouchgrowthanddevelopment.InordertoexaminetheroleofcanonicalWNTsignalingduringpituitarydevelopmentweexaminedthepituitaryexpressionoftheTCF / LEFfamilyoftranscriptionfactors，whichmediateWNTsignalingthroughthebindingofβ-catenin.Wereportheretheexpressionofseveralmembersofthisfamilyduringpituitarydevelopmentandthefunctionalroleofonemember，TCF4（TCF7L2），intheinductionofthepituitaryprimordium.TCF4isexpressedintheventraldiencephalonearlyinpituitarydevelopment，rostraltoadomainofBMPandFGFexpression <位置> TCF4 的deficientmiceexpress <位置> FGF10 和 Bmp4 ;但是， Bmp 和 Fgf 表达域被扩展。结果是，垂体前体细胞sarerecruitedinto Rathkersquo;额外的垂体前体细胞tem4 Tcf4 突变体。 in> expressiondomainwithinRathkersquo; spouch，可能会增加prolif的数量eratingpouchcells，resultinginagreatlyenlargedanteriorpituitarygland.ThissuggeststhatTCF4negativelyregulatespituitarygrowththroughtwomechanisms.ThefirstmechanismistorestrictthedomainsofBMPandFGFsignalingintheventraldiencephalon，andthesecondmechanismistherestrictionof Six6 withinRathkersquo; spouch.Thus，TCF4isnecessarybothintrinsicallyandextrinsicallytoRathkersquo ;. spouchtoensurethepropergrowthofthepituitarygland 展开▼

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《Developmental biology 》 |2007年第2期| 共页

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Michelle L. Brinkmeier; Mary Anne Potok; Shannon W. Davis; Sally A. Camper;
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专利

1. TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors [J] . Brinkmeler ML, Potok MA, Davis SW, Developmental biology . 2007 ,第2期

机译：TCF4缺乏症会扩大腹侧间脑信号传导并增加垂体祖细胞的诱导

2. WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. [J] . Potok MA, Cha KB, Hunt A, Developmental dynamics: an official publication of the American Association of Anatomists . 2008 ,第4期

机译：WNT信号传导影响腹侧脑和垂体生长中的基因表达。

3. WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. [J] . Potok MA, Cha KB, Hunt A, Developmental dynamics: an official publication of the American Association of Anatomists . 2008 ,第6期

机译：WNT信号传导影响腹侧脑和垂体生长中的基因表达。

4. Expanding the Genome Engineering Toolkit: Increasing Signal to Noise [C] . Sandoval N. R. AIChE Annual Meeting . 2015

机译：扩展基因组工程工具包：将信号增加到噪声

5. Beta-catenin signaling occurs in progenitors of the adult nervous system and increases in NG2+ progenitors and astrocytes during posttraumatic gliogenesis. [D] . White, Bryan D. 2009

机译：β-catenin信号传导发生在成人神经系统的祖细胞中，并在创伤后神经胶质发生期间增加NG2 +祖细胞和星形胶质细胞。

6. TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors [O] . Michelle L. Brinkmeier, Mary Anne Potok, Shannon W. Davis, -1

机译：TCF4缺乏症会扩大腹侧二脑信号传导并增加垂体祖细胞的诱导

7. TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors [O] . Brinkmeier Michelle L., Potok Mary Anne, Davis Shannon W., 2007

机译：TCF4缺乏症会扩大腹侧二脑信号传导并增加垂体祖细胞的诱导

1. 血管内皮生长因子体外诱导CD34+造血干/祖细胞信号传导与转录活化因子的活化 [J] . 叶枫 ,叶大风 ,谢幸 . 中国医学科学院学报 . 2004 ,第001期

2. “千方百计扩大出口和增加利用外资”研讨会综述 [J] . 王迎新 . 中国国情国力 . 1999 ,第008期

3. 糖皮质激素通过PI3K/Akt细胞信号传导通路诱导内皮祖细胞功能失调 [A] . 王小红 . 2012

1. Analogous pro-grf fatty body with increased biological potency, pharmaceutical formulation, and, processes for increasing the level of growth hormone, for the diagnosis of growth hormone deficiencies, for the treatment of growth retardation or pituitary dwarfism, wound or healing of bones and osteoporosis in a patient, and to improve protein anabolism in humans or animals. [P] . 外国专利： BR9608799A . 1999-12-07

机译：具有增加的生物效价的类似前脂肪脂肪，药物制剂以及用于增加生长激素水平，诊断生长激素缺乏症，治疗生长迟缓或垂体侏儒症，骨骼伤口或愈合以及骨质疏松症的方法并改善人类或动物的蛋白质合成代谢。

2. methods to increase stem cell production, to increase the number of granulocytes in an individual, to prevent, treat and alleviate myelosuppression that results from cancer therapy, to treat a condition in an individual, to treat neutropenia and thrombocytopenia in a mammal, to expand hematopoietic stem cells in culture, to increase hematopoiesis in an individual, to increase the number of hematopoietic progenitor cells in an individual, and to provide stable bone marrow graft, and, oral dosage form. [P] . 外国专利： BRPI0809670A8 . 2018-12-18

机译：增加干细胞产量，增加个体中粒细胞数量，预防，治疗和减轻癌症治疗导致的骨髓抑制，治疗个体疾病，治疗哺乳动物中性粒细胞减少和血小板减少，扩大造血的方法培养中的干细胞，以增加个体的造血能力，增加个体的造血祖细胞的数量，并提供稳定的骨髓移植物和口服剂型。

3. METHODS FOR INCREASING STEM CELL PRODUCTION, FOR INCREASING THE NUMBER OF GRANULOCYTES IN AN INDIVIDUAL, TO PREVENT, TREAT AND RELIEVE MYELOSUPRESSION THAT RESULT FROM A CANCER THERAPY, TO TREAT A CONDITION IN A INDIVIDUAL A MAMMALIAN, TO EXPAND CELLULAR HEMATOPOETIC TRUNKS IN CULTURE, TO INCREASE HEMATOPYYESIS IN AN INDIVIDUAL, TO INCREASE THE NUMBER OF HEMATOPOETIC PROGENITOR CELLS IN THE FOREIGN AND FOREQUAUS INDEX. [P] . 外国专利： BRPI0809670A2 . 2014-10-07

机译：增加干细胞产量，增加个体中颗粒细胞数量的方法，以预防，治疗和缓解因癌症治疗而引起的骨髓抑制，治疗个体哺乳动物的病情，扩大细胞瘤的发生增加个体的血球增多，以增加外国和前代指数中的造血祖细胞的数量。

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TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors

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