首页> 外文期刊>The Journal of Experomental Medicine >Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.
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Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.

机译:motheaten(me / me)和存活的motheaten(mev / mev)突变小鼠的骨髓中有缺陷的淋巴细胞生成。三,正常的小鼠骨髓细胞可使mev / mev原胸细胞在静脉内转移后产生胸腺细胞。

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Bone marrow prothymocytes from me/me and mev/mev mutant mice fail to generate thymocytes in irradiated (600 rad) +/+ wild-type recipients after intravenous injection. However, these same prothymocytes readily generate thymocytes after intrathymic injection. The results of the present study demonstrate that this apparent defect in the thymus-homing capacity of mev/mev prothymocytes can be corrected by mixing irradiated wild-type bone marrow cells with mev/mev bone marrow cells before intravenous injection. However, this defect is not corrected by passage of mev/mev bone marrow cells through the bone marrow of irradiated wild-type recipients. One interpretation of these results is that the maturation of prothymocytes is reversibly arrested in mev/mev mice by a defect in the radiosensitive compartment of the bone marrow microenvironment.
机译:静脉注射后,来自me / me和mev / mev突变小鼠的骨髓前胸腺细胞无法在受辐照(600 rad)+ / +野生型受体中产生胸腺细胞。然而,这些相同的胸腺细胞在胸腺内注射后容易产生胸腺细胞。本研究的结果表明,通过在静脉内注射之前将辐照的野生型骨髓细胞与mev / mev骨髓细胞混合,可以纠正mev / mev胸腺细胞胸腺归巢能力中的这种明显缺陷。但是,不能通过使mev / mev骨髓细胞通过辐照的野生型受体的骨髓来纠正这种缺陷。这些结果的一种解释是,由于骨髓微环境的放射敏感性区室中的缺陷,在mev / mev小鼠中可逆地阻止了原胸细胞的成熟。

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