A number of continuous human lymphoid cell lines were examined for in vitro synthesis of the effector molecules, lymphotoxin (LT) and migration-inhibition factor (MIF). Twenty-six of a total of 39 lines established from human peripheral blood lymphocytes produced LT activity and 7 of 8 lines assayed secreted MIF. The amounts of LT elaborated varied considerably from one cell line to another and some lines apparently secreted none at all. The cell-toxin secreted in vitro by line 5287 displayed physical properties that were analogous to those of the cell-toxin secreted by phytohemagglutinin-activated normal human lymphocytes.
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