Immunologic studies were performed in mice, guinea pigs and man with cell wall and cytoplasmic fractions of Rickettsia mooseri obtained by mechanical disruption. On a weight basis, cell walls were more effective antigens than either whole rickettsiae or cytoplasmic fraction in the following tests: typhus group complement-fixation and hemagglutination tests and stimulation of antitoxic immunity in mice and anti-infectious immunity in guinea pigs. Cell walls also elicited a delayed type skin reaction in hypersensitive human subjects and a toxic skin reaction in nonsensitive subjects. It was concluded that the antigens involved in these tests were located in or on the cell wall.
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