Surface Antigens of Immunocompetent Cells. IV. Effect of Anti-b5 Allotype on Immunologic Responses of Homozygous b5 Rabbit Cells in vitro

摘要

The investigation of surface receptors on cells of lymphoid tissue has been rigorously pursued in recent years. It is now relatively well established that the receptors which are responsible for the specificity of the bone marrow-derived or B-cell in immunologic reactions consist of immunoglobulin (Ig) molecules. This conclusion was mainly derived from two experimental approaches: 1) the study of the ability of these cells to bind antigen (1–3), and 2) the study of their ability to bind anti-Ig (4–6) and to be killed by anti-Ig and complement (C) (7, 8). These approaches have also been applied toward elucidating the identity of the thymus-derived or T-cell receptor, but have provided conflicting results (4, 6, 9).It has been shown in this laboratory that immune spleen cells from which the majority of B-cells have been killed by anti-Ig and C are severely impaired with respect to their ability to give secondary responses in vitro (10).