A rapid, sensitive and reliable neutralization test for rubella virus (RV) antibody has been described. Test readings were made by observing the interference produced by RV infection with tissue hemadsorption of aged guinea pig red blood cells. Test results could be obtained by this method earlier than by cytopathic effect (CPE) readings. They were found to be more sensitive than those obtained by complement fixation tests and comparable to those obtained by CPE neutralization tests.
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