1. 1. The pigeon is readily sensitized to a foreign protein as here demonstrated by the use of dog's serum.2. 2. When the most favorable sensitizing and critical doses are used, a demonstrable induced sensitiveness occurs on the fourth day, increases rapidly to the tenth day, and reaches a maximum by the twentieth day. It then decreases gradually to disappear between the sixtieth and seventieth days.3. 3. When single or multiple shock reactions are induced in the pigeon, each and every reaction is followed by a definite period of insensitiveness.4. 4. The primary change in blood coagulability during anaphylactic shock is an increase in coagulability, to which a decrease in coagulability is always secondary.
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