Genetic and Cellular Factors in the Immune Response. III. The Cellular Response to Poly(Glu52Lys33Tyr15) in the Highly Responding ACI and Poorly Responding F344 Strains of Inbred Rats

摘要

The antibody response in the inbred rat is controlled by at least two autosomal genes; in addition, there is a sex influence which may include both additional genetic factors and environmental influences (1–3). We postulate that one of the major genes controlling the antibody response influences the size of the cell population initially capable of reacting with the antigen. This hypothesis was tested by measuring the fraction of spleen cells that produced antibody after immunization with poly(Glu52Lys33Tyr15)[1][1] in female rats of the highly responding ACI strain, the poorly responding F344 strain and a hybrid of the two.The inbred ACI and F344 rats were obtained from Microbiological Associates, Walkersville, Md. The hybrid rats were bred in our laboratory starting with an ACI mother and F344 father, and were randomly inbred for three generations. The cellular responses were examined at various time intervals following primary and secondary immunization. [1]: #fn-1