The Preparation of a Potent Toxin of Shigella Dysenteriae (Shiga) on a Semi Synthetic Medium and its Use for the Preparation of an Alum-Precipitated Toxoid

摘要

Shiga toxoid was prepared from cultures of S. dysenteriae on a semi-synthetic medium. Small quantities of this toxoid adsorbed on alum, concentrated, and injected subcutaneously immunized rabbits against multiple lethal doses of toxin.