From the foregoing study there is evidence: 1. 1. Of the presence in horse serum of heterophilic antigens of the Forssman type, as shown by the development of a relatively strong antisheep hemolysin in rabbits immunized with large quantities of the serum. Absorption with heterophilic organs removed the hemolysin, while absorption with non-heterophilic organs diminished its titer only slightly, possibly due to physical absorption. The immune sera did not contain agglutinins for sheep red cells, neither did they contain hemolysins and agglutinins for horse and guinea pig red cells.2. 2. That antistreptococcus serum has antigenic qualities similar to those of plain horse serum, while diphtheria globulin does not stimulate the production of heterophilic antibodies; and that subcutaneous injection of any one of the three sera fails to call forth a response.3. 3. That the sera of rabbits, as a result of treatment, as outlined, become toxic for the guinea pig. This toxicity is shown to be not identical with the sheep cell hemolysin.
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