We directly compared convergent; discriminant and concurrent validity of the Dyspnoea-12 (D-12) and Multidimensional Dyspnoea Profile (MDP) in people with chronic obstructive pulmonary disease.Breathlessness measures (D-12; MDP; visual analogue scales and descriptors) were completed for two focal periods (daily life and end of walk test). Instrument structure (D-12 and MDP item grouping) was assessed with factor analysis. Differences between airflow severity stage and focal periods (ANOVA; t-test and Chi-squared test); associations between D-12 and MDP (r; r2 for static pulmonary function; 6-min walk test and self-reported measures of impairment) and individual consistency for comparable items of the D-12 and MDP (McNemar's test) were assessed.In 84 participants (meanxc2xb1sd age 70xc2xb19xe2x80x85years; 47 males; forced expiratory volume in 1xe2x80x85s 48xc2xb117% predicted); item groupings were confirmed for both focal periods. Developer-recommended single and subdomain scores were highly correlated; and demonstrated similar convergent; discriminant and concurrent validity. Individual consistency differed between the D-12 and MDP according to item/item groups.At the level of developer-recommended single and subdomain scores; the D-12 and MDP share similar psychometric properties; but these instruments serve different purposes; do not assess the same sensations or emotions and are not interchangeable.
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