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外文期刊>The biochemical journal
>The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase
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The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase
pDatabase search using a bovine thymus ubiquitin C-terminal hydrolase sequence indicated 54% sequence identity with the abundant human neuron-specific protein gene product 9.5 (PGP9.5), which was then shown to possess the same activity [Wilkinson, Lee, Deshpande, Duerksen-Hughes, Boss & Pohl (1989) Science 246, 670-673]. A yeast counterpart of the enzyme is also known. The human PGP9.5 gene, described here, spans 10 kb, contains nine exons and displays 5′ features some common to many genes and some common with neurofilament neuron-specific enolase and Thy-1-antigen gene 5′ regions./p
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机译:>使用牛胸腺泛素C末端水解酶序列进行的数据库搜索表明,与丰富的人类神经元特异性蛋白基因产物9.5(PGP9.5)具有54%的序列同一性,然后证明其具有相同的活性[Wilkinson,Lee ,德什潘德,杜克森·休斯,老板和Pohl(1989)Science 246,670-673]。还已知该酶的酵母对应物。这里描述的人类PGP9.5基因跨度为10 kb,包含9个外显子,并显示5'特征,这些特征与许多基因共有,某些与神经丝神经元特异性烯醇化酶和Thy-1-抗原基因5'区域相同。 p >
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