...
首页> 外文期刊>The biochemical journal >Time course of changes in plasma glucose and insulin concentrations and mammary-gland lipogenesis during re-feeding of starved conscious lactating rats
【24h】

Time course of changes in plasma glucose and insulin concentrations and mammary-gland lipogenesis during re-feeding of starved conscious lactating rats

机译:饥饿的清醒哺乳期大鼠进食期间血浆葡萄糖和胰岛素浓度以及乳腺脂肪生成的变化的时程

获取原文
           

摘要

pTemporal changes in circulating insulin concentrations were measured during re-feeding of 18 h-starved lactating rats. Insulin concentrations rose rapidly over the first 20 min of re-feeding with 5 g of chow diet, and then sharply declined between 20-30 min and remained low for the rest of the 90 min experimental period. Lipogenic activity in the mammary gland also exhibited a peak during re-feeding, but there was a clear time lag between the insulin response and the lipogenic response. Blood-flow measurements failed to show any major increase to the tissue during this activation of lipogenesis. Acute suppression of insulin secretion at 30 min (after the initial surge) abolished the switch-on of lipogenesis, suggesting that the insulin-sensitivity of the gland may be acutely enhanced over this period of re-feeding./p
机译:在重新喂养18 h饥饿的哺乳期大鼠期间,测量了循环胰岛素浓度的时间变化。在重新喂食5克食物的最初20分钟内,胰岛素浓度迅速上升,然后在20至30分钟之间急剧下降,并在90分钟的实验期内保持较低水平。乳腺中的脂肪生成活性在补饲过程中也达到峰值,但胰岛素反应和脂肪生成反应之间存在明显的时间差。血流测量未能显示在脂肪形成的激活过程中组织的任何主要增加。在最初的激增后30分钟时,胰岛素分泌的急性抑制作用消除了脂肪生成的开启,这表明在重新喂养期间,腺体的胰岛素敏感性可能会急剧提高。

著录项

获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号