The median effective dosage (ED50) for induction of anesthesia with propofol was determined by using the up-and-down method in 31 unpremedicated cats, in 30 cats premedicated with butorphanol, 0.4 mg/kg body weight (BW), and acepromazine, 0.1 mg/kg BW, intramuscularly, and in 30 cats premedicated with morphine, 0.2 mg/kg BW, and acepromazine, 0.1 mg/kg BW, intramuscularly. The dose required for a satisfactory anesthetic induction in 50% of unpremedicated cats (ED50) was 7.22 mg/kg BW and of premedicated cats was 5.00 mg/kg BW. The reduction in dose was statistically significant in both premedicated groups compared with no premedication. There was no significant difference in ED50 between premedication regimes. Cyanosis was the most common adverse effect observed in all groups following anesthetic induction with propofol.
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机译:通过上下法在31只未用药的猫中,30只用丁苯酚(0.4 mg / kg体重(BW)和乙丙嗪0.1 mg进行过药物治疗的猫)中使用上下方法确定了丙泊酚诱导麻醉的中位有效剂量(ED50)。肌内注射mg / kg体重,在30只经吗啡,0.2 mg / kg BW和乙丙嗪0.1 mg / kg BW进行药物治疗的猫中,进行肌肉注射。在50%未用药的猫中,令人满意的麻醉诱导剂量(ED50)为7.22 mg / kg BW,而用药的猫为5.00 mg / kg BW。与未进行药物治疗相比,在两个药物治疗组中剂量的减少具有统计学意义。术前用药方案之间的ED50没有显着差异。在异丙酚麻醉诱导下,所有组中最常见的不良反应为发。
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