Perinatal Systemic Inflammatory Response Syndrome and Retinopathy of Prematurity

摘要

Fetal and neonatal inflammation is associated with several morbidities of prematurity. Its relationship to retinopathy of prematurity (ROP) has not been investigated. Our objective was to determine the relationship between cytokine levels and ROP in the first 3 postnatal wks. Data for this study were derived from the NICHD Cytokine Study. Dried blood spots (DBS) were obtained from infants Abbreviations: BDNF, brain-derived neurotrophic factor; CRP, C-reactive protein; FIRS, fetal inflammatory response syndrome; GM-CSF, granulocyte-macrophage colony-stimulating factor; IVH, intraventricular hemorrhage; MCP-1, monocyte chemoattractant protein-1; MIP-1α, macrophage inflammatory protein-1α; MMP-9, matrix metalloproteinase-9; NEC, necrotizing enterocolitis; NT-4, neurotrophin-4; PVL, periventricular leukomalacia; RANTES, regulated upon activation, normal T cell expressed and secreted; ROP, retinopathy of prematurity; sIL-6R, soluble IL-6 receptor