Impact of Intravenous Antibiotic Therapy on Total Daily Energy Expenditure and Physical Activity in Cystic Fibrosis Children with Pseudomonas aeruginosa Pulmonary Exacerbation

摘要

Resting energy expenditure (REE) increases during pulmonary exacerbation by Pseudomonas aeruginosa in cystic fibrosis (CF) patients, and decreases after i.v. anti-Pseudomonas aeruginosa antibiotic therapy (IVAT). However, the impact of IVAT on total energy expenditure (TEE) is unknown. The aim of this study was to assess the changes in TEE and its main components after IVAT administered at home. Body composition measured by skinfold thickness and bio-impedance analysis, energy intake (EI) assessed by a weekly diary, REE measured by indirect calorimetry (IC), TEE assessed by a technique using 24-h heart-rate monitoring method and physical activity (PA) monitored using an activity diary (AD) were assessed in 16 patients (9 boys and 7 girls) aged 12.1 ± 2.3 y (range, 7.1–14.6 y), before and after 28 ± 4 d including a 14-d IVAT course. After IVAT, weight increased significantly by 1.9% (32.1 ± 7.5 versus 32.7 ± 7.6 kg; p versus 11,320 ± 3,074 kJ/d; p versus 7,081 ± 1,478 kJ/d) whereas REE decreased by 4.1% (5,295 ± 909 versus 5,093 ± 837 kJ/d; p versus 40.7 ± 4.5 MET; p Abbreviations: AD, activity diary; CF, cystic fibrosis; EE, energy expenditure; EI, energy intake; FFM, fat free mass; FM, fat mass; HR, heart rate; HRMT, heart rate monitoring technique; IC, indirect calorimetry; IVAT, i.v. anti-Pseudomonas aeruginosa antibiotic therapy; PA, physical activity; REE, resting energy expenditure; TEE, total energy expenditure; EE, energy expenditure