We sought a relationship between total and cow's milk-specific IgA levels in colostrum and human milk and subsequent development of cow's milk allergy (CMA) in the breast-fed infant. The study included 87 nursing mothers and their infants (age, 2 d to 7 mo), followed prospectively up to 1 y. At 1 y, 48 mothers (69% with an atopic constitution) had an infant with CMA, verified by clinical cow's milk challenge, eight (38% with an atopic constitution) had a baby who had had protracted infantile colic but no CMA (disease control group), and 31 (23% with an atopic constitution) had a healthy infant. Total breast-milk IgA was measured by radial immunodiffusion, and IgA antibodies to cow's milk were measured by ELISA during the breast-feeding period. The levels of total and cow's milk-specific IgA antibodies in colostrum and human milk were significantly lower in the mothers whose baby later developed CMA [estimated third day value, 0.38 g/L (95% confidence interval, 0.24–0.82)] than in the ones whose infant remained healthy or had had infantile colic but not CMA [0.82 g/L (95% confidence interval, 0.99–1.51);p p Abbreviations: CMA, cow's milk allergy; EU, enzyme immunoassay unit; sIgA, secretory IgA; CI, confidence interval
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机译：我们寻求初乳和人乳中总和特定于牛奶的IgA水平与母乳喂养婴儿对牛奶过敏（CMA）的后续发展之间的关系。这项研究包括87位哺乳期母亲及其婴儿（年龄2 d至7 mo），预期随访时间长达1 y。在1年后，有48名母亲（69％患有特应性体质）患了CMA，并通过临床牛奶挑战证明了这一点，其中8名（38 %%的具有特应性体质）的婴儿有婴儿腹绞痛，但是没有CMA （疾病对照组），其中31例（特应性体质为23％）的婴儿健康。在母乳喂养期间，通过放射免疫扩散法测定了母乳中的总IgA，通过ELISA测定了对牛奶的IgA抗体。初生婴儿和母乳中的母乳中IgA总抗体和母乳特异性IgA抗体的水平明显低于婴儿，其婴儿后来发展为CMA [估计的第三天值为0.38 g / L（95％置信区间为0.24-0.82）]。在婴儿保持健康或患有婴儿绞痛但未发生CMA的婴儿中[0.82 g / L（95％置信区间，0.99-1.51）; pp缩写：CMA，牛奶过敏; EU，酶免疫测定单位; sIgA，分泌型IgA; CI，置信区间
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