13 EVALUTION OF THE EFFICACY OF GROWTH HORMONE TREATMENT WITH RECOMBINANT HUMAN GROWTH HORMONE |[lpar]|rhGH|[rpar]| IN |[ldquo]|SHORT NORMAL|[rdquo]| CHILDREN WITHOUT GH DEFICIENCY

摘要

Some children with GH deficiency on tests fro grewth hormone secretion and with normal laboratory evaluation for short stature, present abnormal growth velocity (GV) or predict adult height (PAH) balcw the target height (TH); probably they will not attain a final height in accordance with their genetical potential. We studied 14 of those children: 8 boys and 6 girls, ages between 8 and 12.4 years (14=10.0 y). Eight children were classified as familial short stature and 4 as “idiopathic” short stature: 2 other had abnormal GV. rhGH, 1 U/kg/week, SC, in daily dosis was given. Six children with pubertal signs (Tanner stages II and III) ware treated concomitantly with long acting LH-RH analog (Decapeptyl 3 mg, IM, monthly). The results of the treatment at 6 (14 patients) and at 12 months (5 patients) were:No side effects were observed and TSH, T4, T3, glyomia and urine analysis were normal. In agreement with literature these results suggest that to some “short normal” children the use of rhGH could increase the final height.