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>Birth Weight Deviation and Early Postnatal Growth Are Related to Optic Nerve Morphology at School Age in Children Born Preterm
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Birth Weight Deviation and Early Postnatal Growth Are Related to Optic Nerve Morphology at School Age in Children Born Preterm
The aim of this study was to evaluate the influence of early and later postnatal growth variables on optic disc morphology in children (n = 53) born at gestational age n = 203). The results were analyzed in relation to gestational age, birth weight (BW) SD score (SDS), IGF-1 weight at postmenstrual age 32 wk (SDS), and weight, length, and head circumference (SDS) at follow-up. The preterm children's optic disc and neuronal rim areas were smaller than in the control group. Low BW (SDS) and weight at wk 32 (SDS) were associated with larger area of the optic cup and reduced neuronal rim area. Preterm children with known brain lesions (n = 6) had significantly larger cups than preterm children without known brain lesions. The association found between both low BW and poor early growth and later reduced neuronal tissue of the optic nerve indicate that early weight gain is important for neural development in preterm children.Abbreviations: BW, birth weight; GA, gestational age; IVH, intraventricular hemorrhage; PVL, periventricular leucomalacia; ROP, retinopathy of prematurity; SGA, small for gestational age; WMD, white matter damage
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